John Howard Payne leaves home and begins a career in the theater. Despite encouragement from his mother and his sweetheart, Payne begins to lead a life of dissolute habits, and this soon leads to ruin and misery. In deep despair, he thinks of better days, and writes a song that later provides inspiration to several others in their own times of need.

Two brothers, Phil and Ted Stoneman, visit their friends in Piedmont, South Carolina: the family Cameron. This friendship is affected by the Civil War, as the Stonemans and the Camerons must join up opposite armies. The consequences of the War in their lives are shown in connection to major historical events, like the development of the Civil War itself, Lincoln's assassination, and the birth of the Ku Klux Klan.